Iranian authorities stated that Khademi was targeted earlier in the day, marking another high-profile casualty amid the ongoing conflict.
Khademi had assumed the role in 2025 after his predecessor, Mohammad Kazemi, was killed in an earlier Israeli strike during a brief but intense confrontation between Iran and Israel.
His death underscores the continued vulnerability of top Iranian officials amid escalating hostilities in the region.
Iran has directly accused both Washington and Tel Aviv of orchestrating the attack. However, the Israel Defense Forces has not officially confirmed involvement, stating only that it is reviewing the reports.
The development is expected to further strain relations and could trigger retaliatory actions from Tehran.
Earlier this year, Khademi had publicly criticized Donald Trump, accusing the US of encouraging instability within Iran. He had also alleged involvement of multiple foreign intelligence agencies in domestic unrest.
These remarks came in the wake of widespread protests and a subsequent crackdown that reportedly led to significant casualties.
The killing adds to a growing list of targeted strikes and counter-allegations between Iran, the US, and Israel. Analysts warn that such developments could deepen the conflict and increase the risk of a broader regional escalation.
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